Aflatoxin B1

A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.

Also Known As:

Aflatoxin B; Aflatoxin B1 Dihydrochloride, (6aR-cis)-Isomer; Aflatoxin B1, (6aR-cis)-Isomer, 14C-Labeled; Aflatoxin B1, (6aR-cis)-Isomer, 2H-Labeled; Aflatoxin B1, (6aR-cis)-Isomer, 3H-Labeled; Aflatoxin B1, cis(+,-)-Isomer; HSDB-3453; NSC-529592; HSDB 3453; HSDB3453; NSC 529592; NSC529592; Aflatoxin B(1); Cyclopenta(c)furo(3',2':4,5)furo(2,3- h)(1)benzopyran- 1,11- dione, 2,3,6a,9a-tetrahydro-4-methoxy-, (6aR-cis)-

Pharmalogical Action Categories:

Poisons

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Aflatoxins: 1770
        Aflatoxin B1: 1058
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Aflatoxins: 1770
        Aflatoxin B1: 1058
Biological Factors: 2472
- Biological Toxins: 20
  - Mycotoxins: 1745
    - Aflatoxins: 1770
      - Aflatoxin B1: 1058

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Disease

Drug/Important Bio-Agent (IBA)

Therapy/Procedure